Cardiovascular & Hematological Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Debabrata Mukherjee
Department of Internal Medicine Texas Tech University
4800 Alberta Avenue El Paso
Texas, 79905


Advances in Sickle Cell Disease Treatment: from Drug Discovery Until the Patient Monitoring

Author(s): Jean Leandro dos Santos, Carolina Lanaro and Chung Man Chin

Affiliation: Lapdesf–Laboratorio de Pesquisa e Desenvolvimento de Farmacos, Departamento de Farmacos e Medicamentos, Faculdade de Ciencias Farmaceuticas–Universidade Estadual Paulista–UNESP, Rodovia Araraquara Jau Km. 01, 14801-902,Araraquara, SP, Brazil.


Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. Nowadays the treatment is performed mainly with drugs such as hydroxyurea or other fetal hemoglobin inducers and chelating agents. This review summarizes current knowledge about the treatment and the advancements in drug design in order to discover more effective and safe drugs. Patient monitoring methods in SCD are also discussed.

Keywords: Drug discovery, hydroxyurea, patient monitoring, sickle cell, sickle cell treatment, new drugs, fetal hemoglobin, chelating agents, gardos channel, poloxamer 188, gene therapy, stem cell transplant, hemoglobin modifiers, nitric oxide

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Article Details

Page: [113 - 127]
Pages: 15
DOI: 10.2174/187152511796196506