Cardiovascular & Hematological Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Debabrata Mukherjee
Department of Internal Medicine Texas Tech University
4800 Alberta Avenue El Paso
Texas, 79905
USA

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Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis

Author(s): Nicolas Clere, Sebastien Faure, Maria Carmen Martinez and Ramaroson Andriantsitohaina

Affiliation: INSERM UMR U694, PBH -IRIS, Rue des Capucins, F-49100 Angers, France.

Keywords: Flavonoids, apigenin, EGCG, delphinidin, genistein, angiogenesis, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor microenvironment

Abstract:

High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.

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Article Details

VOLUME: 9
ISSUE: 2
Page: [62 - 77]
Pages: 16
DOI: 10.2174/187152511796196498