Abstract
Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in the late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if too broad an effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.
Keywords: Topiramate, addictions, treatment, drug abuse, dysfunctional, hedonic, ritualized, amphetamines, morphine, naltrexone, mesolimbic, synaptic, neuroanatomical, vaccines, ethanol, sensitization, kainate
Current Pharmaceutical Design
Title: The Potential Interest of Topiramate in Addictions
Volume: 17 Issue: 14
Author(s): Gabriel Thorens, Joel Billieux, Rita Manghi, Riaz Khan, Yasser Khazaal and Daniele Fabio Zullino
Affiliation:
Keywords: Topiramate, addictions, treatment, drug abuse, dysfunctional, hedonic, ritualized, amphetamines, morphine, naltrexone, mesolimbic, synaptic, neuroanatomical, vaccines, ethanol, sensitization, kainate
Abstract: Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in the late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if too broad an effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.
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Cite this article as:
Thorens Gabriel, Billieux Joel, Manghi Rita, Khan Riaz, Khazaal Yasser and Fabio Zullino Daniele, The Potential Interest of Topiramate in Addictions, Current Pharmaceutical Design 2011; 17 (14) . https://dx.doi.org/10.2174/138161211796150864
DOI https://dx.doi.org/10.2174/138161211796150864 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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