Current Neuropharmacology

T.E. Salt
University College London
Institute of Ophthalmology
London EC1V 9EL
UK

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Neuroprotection: The Emerging Concept of Restorative Neural Stem Cell Biology for the Treatment of Neurodegenerative Diseases

Author(s): Fiorella Piemonte, Ferdinando Rossi and Barbara Carletti

Affiliation: Unit of Neuromuscular and Neurodegenerative diseases, Children's Hospital and Research Institute “Bambino Gesu”, P.za S. Onofrio, 4, 00165 Rome, Italy.

Abstract:

During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare parts for cell replacement therapies, NSCs could play a key role in the pharmacology of neuroprotection and become protagonists of innovative treatments for neurodegenerative diseases. Here, we review this new emerging concept of NSC biology.

Keywords: neurocytoprotective, degenerative processes, inflammationrelated processes, neurodegenerative diseases, mitochondrial dysfunction, oxidative stress, neurotrophic factors, neuroprotection, neurodegenerative disorders, Neural stem cells

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Article Details

VOLUME: 9
ISSUE: 2
Page: [313 - 317]
Pages: 5
DOI: 10.2174/157015911795596603
Price: $58