Abstract
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and non-surgical ones, cannot effectively cure this disease. Increasing evidence has revealed the importance of cancer stem cells (CSCs) in hepatocarcinogenesis, and the idea of targeting CSCs sheds light on more effective therapeutic strategies for HCC. In this review, normal stem cells and putative CSCs in the liver are briefly introduced. Studies about signaling pathways that regulate pathophysiological activities of liver CSCs and the therapeutic potential by targeting CSCs are also summarized and discussed.
Keywords: Normal stem cells, cancer stem cells, hepatocellular carcinoma, Epidemiology, chemoembolization, angiogenesis, hydrolase, EpCAM, CD13, CD90, NOTCH, OVAL CELLS, PTEN, TGF
Anti-Cancer Agents in Medicinal Chemistry
Title: Role of Stem Cells in Normal Liver and Cancer
Volume: 11 Issue: 6
Author(s): Chi Keung Lau, Zhen Fan Yang and Sheung Tat Fan
Affiliation:
Keywords: Normal stem cells, cancer stem cells, hepatocellular carcinoma, Epidemiology, chemoembolization, angiogenesis, hydrolase, EpCAM, CD13, CD90, NOTCH, OVAL CELLS, PTEN, TGF
Abstract: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and non-surgical ones, cannot effectively cure this disease. Increasing evidence has revealed the importance of cancer stem cells (CSCs) in hepatocarcinogenesis, and the idea of targeting CSCs sheds light on more effective therapeutic strategies for HCC. In this review, normal stem cells and putative CSCs in the liver are briefly introduced. Studies about signaling pathways that regulate pathophysiological activities of liver CSCs and the therapeutic potential by targeting CSCs are also summarized and discussed.
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Cite this article as:
Keung Lau Chi, Fan Yang Zhen and Tat Fan Sheung, Role of Stem Cells in Normal Liver and Cancer, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (6) . https://dx.doi.org/10.2174/187152011796011091
DOI https://dx.doi.org/10.2174/187152011796011091 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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