Endocytic Trafficking and Wnt/β-Catenin Signaling

Author(s): Oscar Pellon-Cardenas, Jill Schweitzer, Crislyn D'Souza-Schorey.

Journal Name: Current Drug Targets

Volume 12 , Issue 8 , 2011

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Abstract:

Several mechanisms function in the endocytic regulation of the Wnt/β-catenin signaling pathway to promote or interrupt the progression of critical cellular processes during embryonic development or disease progression. Endocytosis was initially associated with the formation of a morphogen gradient of Wnt/β-catenin signaling, but current studies have documented its role in defining signal intensity and propagation. Although the exact parameters that define and dictate the internalization of Wnt receptors and co-receptors via clathrin- or caveolae-mediated endocytosis remain unclear, new studies indicate that the trafficking of the signaling pool of the dual-function protein β-catenin from sites of cell-cell contacts serve as a mechanism to finely tune the outcome of the Wnt/β-catenin signaling. This review discusses the endocytic regulation of Wnt/ β-catenin signaling that occurs at the cell surface as well as within the cell.

Keywords: Endocytosis, Wnt, β-catenin, LRP6, cell adhesion, cell signaling, GTPases, transcription factor, endocytic portal, trafficking

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Article Details

VOLUME: 12
ISSUE: 8
Year: 2011
Page: [1216 - 1222]
Pages: 7
DOI: 10.2174/138945011795906552
Price: $58

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