PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

Author(s): MaLing Gou, XiaWei Wei, Ke Men, BiLan Wang, Feng Luo, Xia Zhao, YuQuan Wei, ZhiYong Qian.

Journal Name: Current Drug Targets

Volume 12 , Issue 8 , 2011

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Abstract:

Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(- caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.

Keywords: Biodegradable polymer, cancer, diagnostic agent, drug delivery system, gene delivery, nanoparticle, poly(-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers, vaccine, nano-precipitation method, chemotherapy

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Article Details

VOLUME: 12
ISSUE: 8
Year: 2011
Page: [1131 - 1150]
Pages: 20
DOI: 10.2174/138945011795906642
Price: $58

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