Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex


Superoxide Dismutase in Redox Biology: The Roles of Superoxide and Hydrogen Peroxide

Author(s): Garry R. Buettner

Affiliation: Free Radical and Radiation Biology, Med Labs B180, The University of Iowa, Iowa City, IA 52242-1181.


Superoxide dismutases (SOD) are considered to be antioxidant enzymes. This view came about because its substrate, superoxide, is a free radical; in the era of their discovery, 1960s – 1970s, the general mindset was that free radicals in biology must be damaging. Indeed SOD blunts the cascade of oxidations initiated by superoxide. However in the late 1970s it was observed that cancer cells that have low activity of the mitochondrial form of SOD, MnSOD, grow faster than those with higher activities of MnSOD. These observations indicated that SOD, superoxide, and hydrogen peroxide affected the basic biology of cells and tissues, not just via damaging oxidation reactions. It is now realized that superoxide and hydrogen peroxide are essential for normal cellular and organism function. MnSOD appears to be a central player in the redox biology of cells and tissues.

Keywords: Superoxide dismutase, mitochondria, coenzyme Q, hydrogen peroxide, superoxide, redox environment, hypoxia inducible factor, iron, melanoma cells, reduction, xanthine oxidase, tocopherol, low-flux signaling circuits, hypoxia, histidines

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Article Details

Page: [341 - 346]
Pages: 6
DOI: 10.2174/187152011795677544
Price: $58