Abstract
Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40 – 70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity
Keywords: Obesity, aCGH, chromosome, deletion, duplication, translocation, fluorescent in situ hybridization, CNV, congenital anomalies, growth retardation
Current Genomics
Title: Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature
Volume: 12 Issue: 3
Author(s): Majed J. Dasouki, Erin L. Youngs and Karine Hovanes
Affiliation:
Keywords: Obesity, aCGH, chromosome, deletion, duplication, translocation, fluorescent in situ hybridization, CNV, congenital anomalies, growth retardation
Abstract: Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40 – 70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity
Export Options
About this article
Cite this article as:
J. Dasouki Majed, L. Youngs Erin and Hovanes Karine, Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature, Current Genomics 2011; 12 (3) . https://dx.doi.org/10.2174/138920211795677930
DOI https://dx.doi.org/10.2174/138920211795677930 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Noncardiac Surgery: Evaluating and Minimizing Cardiac Risk
Current Cardiology Reviews Mechanical Ventilation Following Cardiac Surgery in Children
Current Respiratory Medicine Reviews Cardiovascular Diseases in Pregnancy - A Brief Overview
Current Cardiology Reviews Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition
Current Drug Targets A Comparative Effectiveness Systematic Review and Meta-analysis of Drugs for the Prophylaxis of Junctional Ectopic Tachycardia
Current Cardiology Reviews Frequency of Cardiac Arrhythmias in Children with Cardiological Consulting and Containing Electrocardiogram
Cardiovascular & Hematological Disorders-Drug Targets The Role of Beta-Blocker in Heart Failure in Adults with Congenital Heart Disease
Reviews on Recent Clinical Trials Genetics of Congenital Heart Disease
Current Cardiology Reviews Human Induced Pluripotent Stem Cells for Inherited Cardiovascular Diseases Modeling
Current Stem Cell Research & Therapy Mending a Broken Heart: Bioengineered Patches and Scaffolds for Cardiac Repair
Recent Patents on Biomedical Engineering (Discontinued) Characterization of Supraventricular Tachycardia in Infants: Clinical and Instrumental Diagnosis
Current Pharmaceutical Design Predictors of Ominous Outcome in Infants who Undergo Cardiac Surgery and Cardiopulmonary By-Pass: S100B Protein
CNS & Neurological Disorders - Drug Targets Troponin in Newborns and Pediatric Patients
Cardiovascular & Hematological Agents in Medicinal Chemistry Medical Treatment of Aortic Aneurysms in Marfan Syndrome and other Heritable Conditions
Current Cardiology Reviews Role of Genetic Factors in the Pathogenesis of Radial Deficiencies in Humans
Current Genomics The Right Ventricle: Biologic Insights and Response to Disease
Current Cardiology Reviews Mechanistic Approach to Understanding Psychosis Risk in Velocardiofacial Syndrome
Current Pediatric Reviews A Review of Systemic Vasodilators in Low Cardiac Output Syndrome Following Pediatric Cardiac Surgery
Current Vascular Pharmacology Targeting Notch as a Therapeutic Approach for Human Malignancies
Current Pharmaceutical Design Repair of Dilated Aortic Root and Sinotubular Junction Using a Stabilizer Ring
Recent Patents on Cardiovascular Drug Discovery