PLACD-7T Study: Atherosclerotic Carotid Plaque Components Correlated with Cerebral Damage at 7 Tesla Magnetic Resonance Imaging

Author(s): A. G. den Hartog, S. M. Bovens, W. Koning, J. Hendrikse, G. Pasterkamp, F. L. Moll, G. J. de Borst.

Journal Name: Current Cardiology Reviews

Volume 7 , Issue 1 , 2011

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Abstract:

Introduction: In patients with carotid artery stenosis histological plaque composition is associated with plaque stability and with presenting symptomatology. Preferentially, plaque vulnerability should be taken into account in pre-operative work-up of patients with severe carotid artery stenosis. However, currently no appropriate and conclusive (non-) invasive technique to differentiate between the high and low risk carotid artery plaque in vivo is available. We propose that 7 Tesla human high resolution MRI scanning will visualize carotid plaque characteristics more precisely and will enable correlation of these specific components with cerebral damage.

Study objective: The aim of the PlaCD-7T study is 1: to correlate 7T imaging with carotid plaque histology (gold standard); and 2: to correlate plaque characteristics with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds) on 7 Tesla high resolution (HR) MRI.

Design: We propose a single center prospective study for either symptomatic or asymptomatic patients with haemodynamic significant (70%) stenosis of at least one of the carotid arteries. The Athero-Express (AE) biobank histological analysis will be derived according to standard protocol. Patients included in the AE and our prospective study will undergo a pre-operative 7 Tesla HR-MRI scan of both the head and neck area.

Discussion: We hypothesize that the 7 Tesla MRI scanner will allow early identification of high risk carotid plaques being associated with micro infarcted cerebral areas, and will thus be able to identify patients with a high risk of periprocedural stroke, by identification of surrogate measures of increased cardiovascular risk.

Keywords: 7 Tesla MRI, carotid plaque, cerebral damage, ahistology, PLACID-7T, stenosis, symptomatology, invasive techniques, asymptomatic, ipsilateral carotid stenosis, carotid plaque phenotype, intra-paque markers, thrombo-embolic

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2011
Page: [28 - 34]
Pages: 7
DOI: 10.2174/157340311795677743

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