Abstract
Indoleamine 2,3-dioxygenase (IDO) is an intracellular heme-containing enzyme that catalyzes the initial rate-limiting step in tryptophan degradation along the kynurenine pathway. Recent works have demonstrated a crucial role for IDO in the induction of immune tolerance during infections, pregnancy, transplantation, autoimmunity, and neoplasias. IDO is widely expressed in human tissues and cell subsets, including dendritic cells, where it modulates their function by increasing tolerogenic capacities. The aim of the present paper is to highlight the most recent data about IDO expression in dendritic cells and its role as a potent inducer of T regulatory cells.
Keywords: T regulatory cells, indoleamine 2,3-dioxygenase, dendritic cells, intracellular heme-containing enzyme, tryptophan degradation, kynurenine, IDO, immune tolerance, neoplasias, tolerogenic capacities
Current Medicinal Chemistry
Title: Induction of Regulatory T Cells by Dendritic Cells through Indoleamine 2,3- dioxygenase: A Potent Mechanism of Acquired Peripheral Tolerance
Volume: 18 Issue: 15
Author(s): S. Trabanelli, D. Ocadlikova, C. Evangelisti, S. Parisi and A. Curti
Affiliation:
Keywords: T regulatory cells, indoleamine 2,3-dioxygenase, dendritic cells, intracellular heme-containing enzyme, tryptophan degradation, kynurenine, IDO, immune tolerance, neoplasias, tolerogenic capacities
Abstract: Indoleamine 2,3-dioxygenase (IDO) is an intracellular heme-containing enzyme that catalyzes the initial rate-limiting step in tryptophan degradation along the kynurenine pathway. Recent works have demonstrated a crucial role for IDO in the induction of immune tolerance during infections, pregnancy, transplantation, autoimmunity, and neoplasias. IDO is widely expressed in human tissues and cell subsets, including dendritic cells, where it modulates their function by increasing tolerogenic capacities. The aim of the present paper is to highlight the most recent data about IDO expression in dendritic cells and its role as a potent inducer of T regulatory cells.
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Trabanelli S., Ocadlikova D., Evangelisti C., Parisi S. and Curti A., Induction of Regulatory T Cells by Dendritic Cells through Indoleamine 2,3- dioxygenase: A Potent Mechanism of Acquired Peripheral Tolerance, Current Medicinal Chemistry 2011; 18 (15) . https://dx.doi.org/10.2174/092986711795656054
DOI https://dx.doi.org/10.2174/092986711795656054 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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