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PC12 Interaction with Magnetic Nanotubes: Effects on Viability, Cell Differentiation and Cell Translocation Induced by a Magnetic Field

Author(s): Orazio Vittorio, Vittoria Raffa, Cristina Riggio, Andrea Pietrabissa, Alfred Cuschieri.

Abstract:

In this paper we used Multi Wall Carbon Nanotubes (MWCNTs) containing 3% of residuals and impurities of Fe, Al, and Zn. MWCNTs, by virtue of Fe at their tips, are able to respond to the effects of external magnetic fields. We demonstrated that MWCNTs interact with PC12 cells without compromising their viability and differentiation with outgrowth of neurites. We also document that when exposed to a magnetic field, both undifferentiated and differentiated PC12 cells cultured in CNT-containing medium solution are able to move towards the magnetic source.

Keywords: Nanoparticles, magnetic materials, cell displacement, neuronal differentiation, anti-allodynia, antinociception, neuropathic pain, chronic pain, in vitro release, Franz diffusion cells, PLGA nanoparticles, amitriptyline, doxepin, imipramine, tricyclic antidepressants, Korsmeyer-Peppas

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2011
Page: [337 - 344]
Pages: 8
DOI: 10.2174/157341311795542499
Price: $58