Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Mitochondrial Tolerance to Drugs and Toxic Agents in Ageing and Disease

Author(s): Jan Suski, Magdalena Lebiedzinska, Nuno G. Machado, Paulo J. Oliveira, Paolo Pinton, Jerzy Duszynski and Mariusz R. Wieckowski

Affiliation: Laboratory of Bioenergetics and Biomembranes, Department of Biochemistry, Nencki Institute ofExperimental Biology, Pasteur 3 St., 02-093 Warsaw, Poland.

Keywords: Mitochondria, ageing, drugs, toxic agents, respiratory chain, oxidative phosphorylation, oxidative stress, ROS, hispidin, antiretroviral therapy


Better understanding of the effect of ageing on mitochondrial metabolism and of the mechanisms of action of various drugs is required to allow optimization of the treatment of many diseases with minimized risk of dangerous impairment of mitochondrial function. Numerous reports show that efficacy of medical treatment depends on the age of treated subjects. This applies particularly to the effect of drugs on various senescence-prone cellular pathways. In this review, we demonstrate how ageing affects various mitochondria-associated pathways and their response to a variety of factors. These factors include registered drugs and other chemicals, and account for diverse consequences which vary depending on the physiological condition. Pharmacological treatments aimed at improving mitochondrial function should thus have in mind the subject age.

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Article Details

Page: [827 - 849]
Pages: 23
DOI: 10.2174/138945011795529029