Mild Mitochondrial Uncoupling as a Therapeutic Strategy

Author(s): Fernanda M. Cunha, Camille C. Caldeira da Silva, Fernanda M. Cerqueira, Alicia J. Kowaltowski.

Journal Name:Current Drug Targets

Volume 12 , Issue 6 , 2011

Abstract:

Mild mitochondrial uncoupling, or the reduction of the efficiency of energy conversion without compromising intracellular high energy phosphate levels, is a protective therapeutic strategy under many laboratory conditions. Here we discuss these conditions, which include both cell and animal models of ischemia reperfusion and complications associated with the metabolic syndrome. We also discuss drugs that promote mild mitochondrial uncoupling and naturally occurring mild mitochondrial uncoupling pathways involving free fatty acid cycling and K+ transport.

Keywords: Mitochondria, uncoupler, dinitrophenol, uncoupling protein, adenine nucleotide translocator, ATP-sensitive K+ channels, redox sensitive pathways, ROS release, energy metabolism, flavoenzymes

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Article Details

VOLUME: 12
ISSUE: 6
Year: 2011
Page: [783 - 789]
Pages: 7
DOI: 10.2174/138945011795528778
Price: $58