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Current Drug Targets
ISSN (Print): 1389-4501
ISSN (Online): 1873-5592
VOLUME: 12
ISSUE: 6
DOI: 10.2174/138945011795528985      Price:  $58









Investigating Mitochondrial Dysfunction to Increase Drug Safety in the Pharmaceutical Industry

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Author(s): Sashi Nadanaciva and Yvonne Will
Pages 774-782 (9)
Abstract:
Drug-induced mitochondrial dysfunction is a contributor to both late-stage compound attrition and post-market drug withdrawals. This review outlines the mechanisms which lead to drug-induced mitochondrial dysfunction and discusses the tremendous advances that have been made in the development of in vitro methods to identify mitochondrial impairment. Potentially useful animal models and in vivo methods to detect drug-induced mitochondrial impairment are also discussed.
Keywords:
Mitochondrial dysfunction, oxidative phosphorylation, organ toxicity, mitochondrial diseases, drug safety, bioenergetics, mutation, metabolomics, dyslipidemia, NSAID, water, synthesis, organic
Affiliation:
Compound Safety Prediction, Pfizer Global R, Eastern Point Rd, Groton CT, 06340, USA.