Gene Expression Significance in Personalized Medicine of Non-small Cell Lung Cancer and Gene Expression Analyzing Platforms

Author(s): Li Zhang, Huiyi Yang, Jiasen Xu.

Journal Name: Current Drug Metabolism

Volume 12 , Issue 5 , 2011

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Abstract:

The association between gene expression and clinical characteristics of non-small cell lung cancer (NSCLC) are uncovered. These genes are critical elements in carcinoma physiological processes, including DNA synthesis, DNA repair and mitosis. Genes such as ERCC1, RRM1, TYMS, TUBB3 and STMN1 are predictive biomarker candidates for chemotherapy sensitivity in patients with NSCLC. Suitable gene expression analyzing technology is key factor for the personalize medicine to become a reality. This mini-review will describe and discuss critically on most currently widely used gene expression analyzing technologies, involving immunohistochemistry (IHC), reverse-transcription quantitative PCR (RT-qPCR) and branch-DNA technology (bDNA).

Keywords: bDNA, gene expression, immunohistochemistry, predictive biomarkers, quantitative assays, RT-PCR, carcinoma, mitosis, DNA synthesis, reverse-transcription quantitative PCR (RT-qPCR)

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2011
Page: [455 - 459]
Pages: 5
DOI: 10.2174/138920011795495303
Price: $58

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