Harnessing Impaired Energy Metabolism in Cancer Cell: Small Molecule- Mediated Ways to Regulate Tumorigenesis

Author(s): Govardhan K. Shroff, Ramyasri Kuna, Kethora Dirsipam, Ravishekar Yalagala, Prasenjit Mitra.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 11 , Issue 3 , 2011

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Abstract:

Altered cellular metabolism is a hallmark of tumorigenesis. Described first in 1924 by Otto Warburg, a cancer cell undergoes complete metabolic reprogramming to attain nutrient self-sufficiency for proliferation and survival. Interplay between diverse signalling cascades confers this metabolic advantage. In this review we focus on signalling molecules that regulate this altered metabolic paradigm in a cancer cell with emphasis on small molecule mediated intervention for attenuation of growth and progression of tumor.

Keywords: Warburg effect, glutaminolysis, aerobic glycolysis, Myc, Akt, mTOR, Hexokinase II, SGLT2 expression, mitochondrial outer membrane, isozymes, Fibroblast growth factor receptor (FGFR), Pyruvate kinase, tumor cell populations, hypoxic tumor cells

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2011
Page: [272 - 279]
Pages: 8
DOI: 10.2174/187152011795347531
Price: $58

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