Abstract
Garlic and garlic-derived compounds reduce the development of mammary cancer in animals and suppress the growth of human breast cancer cells in culture. Oil-soluble compounds derived from garlic, such as diallyl disulfide (DADS), are more effective than water-soluble compounds in suppressing breast cancer. Mechanisms of action include the activation of metabolizing enzymes that detoxify carcinogens, the suppression of DNA adduct formation, the inhibition of the production of reactive oxygen species, the regulation of cell-cycle arrest and the induction of apoptosis. Selenium-enriched garlic or organoselenium compounds provide more potent protection against mammary carcinogenesis in rats and greater inhibition of breast cancer cells in culture than natural garlic or the respective organosulfur analogues. DADS synergizes the effect of eicosapentaenoic acid, a breast cancer suppressor, and antagonizes the effect of linoleic acid, a breast cancer enhancer. Moreover, garlic extract reduces the side effects caused by anti-cancer agents. Thus, garlic and garlic-derived compounds are promising candidates for breast cancer control.
Keywords: Garlic, breast, mammary, diallyl disulfide (DADS), selenium, 7,12-dimethylbenz anthracene (DMBA), N-methyl-Nnitrosourea (MNU), apoptosis, Diallyl trisulfide, ORGANOSULFUR COMPOUNDS, Allicin, SELENIUM-ENRICHED GARLIC, diallyl selenide (DASe), seleniummethylselenocysteine (SeMSC), DADS
Anti-Cancer Agents in Medicinal Chemistry
Title: Anticancer Effects of Garlic and Garlic-derived Compounds for Breast Cancer Control
Volume: 11 Issue: 3
Author(s): Airo Tsubura, Yen-Chang Lai, Maki Kuwata, Norihisa Uehara and Katsuhiko Yoshizawa
Affiliation:
Keywords: Garlic, breast, mammary, diallyl disulfide (DADS), selenium, 7,12-dimethylbenz anthracene (DMBA), N-methyl-Nnitrosourea (MNU), apoptosis, Diallyl trisulfide, ORGANOSULFUR COMPOUNDS, Allicin, SELENIUM-ENRICHED GARLIC, diallyl selenide (DASe), seleniummethylselenocysteine (SeMSC), DADS
Abstract: Garlic and garlic-derived compounds reduce the development of mammary cancer in animals and suppress the growth of human breast cancer cells in culture. Oil-soluble compounds derived from garlic, such as diallyl disulfide (DADS), are more effective than water-soluble compounds in suppressing breast cancer. Mechanisms of action include the activation of metabolizing enzymes that detoxify carcinogens, the suppression of DNA adduct formation, the inhibition of the production of reactive oxygen species, the regulation of cell-cycle arrest and the induction of apoptosis. Selenium-enriched garlic or organoselenium compounds provide more potent protection against mammary carcinogenesis in rats and greater inhibition of breast cancer cells in culture than natural garlic or the respective organosulfur analogues. DADS synergizes the effect of eicosapentaenoic acid, a breast cancer suppressor, and antagonizes the effect of linoleic acid, a breast cancer enhancer. Moreover, garlic extract reduces the side effects caused by anti-cancer agents. Thus, garlic and garlic-derived compounds are promising candidates for breast cancer control.
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Cite this article as:
Tsubura Airo, Lai Yen-Chang, Kuwata Maki, Uehara Norihisa and Yoshizawa Katsuhiko, Anticancer Effects of Garlic and Garlic-derived Compounds for Breast Cancer Control, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (3) . https://dx.doi.org/10.2174/187152011795347441
DOI https://dx.doi.org/10.2174/187152011795347441 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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