Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins

Author(s): Jonathan F. Arambula, Christian Preihs, Derric Borthwick, Darren Magda, Jonathan L. Sessler.

Abstract:

Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimentaluse in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.

Keywords: Texaphyrin, reactive oxygen species, anticancer activity, mechanism of action, zinc, platinum delivery, alpha and beta core emitters, superoxide dismutase, amyotrophic lateral sclerosis (ALS), Parkinson's Disease (PD), Alzheimer's Disease (AD), hydroquinones, chronic lymphocytic leukemia (CLL), Gd-oxalate-Gd bridging interactions, NAD levels

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2011
Page: [222 - 232]
Pages: 11
DOI: 10.2174/187152011795255894
Price: $58