Abstract
The family of superoxide dismutases (SODs) are well known for their antioxidant actions exerted by catalyzing the conversion of O2˙- into H2O2 plus oxygen. The importance of this action is revealed by the multiple phenotypic deficits exhibited by a variety of organisms that have been made to lack one or more of the SODs. Never the less there have been reports of deleterious consequences caused by overproduction of SOD. Several explanations have been proposed for these counter intuitive effects; one of which is that elevated SOD causes increased formation of H2O2. The reasons for dismissing this explanation are explored.
Keywords: Superoxide, Hydrogen peroxide, Superoxide dismutases, Catalases, Peroxidases
Anti-Cancer Agents in Medicinal Chemistry
Title: Superoxide Dismutases: Anti- Versus Pro- Oxidants?
Volume: 11 Issue: 2
Author(s): Irwin Fridovich
Affiliation:
Keywords: Superoxide, Hydrogen peroxide, Superoxide dismutases, Catalases, Peroxidases
Abstract: The family of superoxide dismutases (SODs) are well known for their antioxidant actions exerted by catalyzing the conversion of O2˙- into H2O2 plus oxygen. The importance of this action is revealed by the multiple phenotypic deficits exhibited by a variety of organisms that have been made to lack one or more of the SODs. Never the less there have been reports of deleterious consequences caused by overproduction of SOD. Several explanations have been proposed for these counter intuitive effects; one of which is that elevated SOD causes increased formation of H2O2. The reasons for dismissing this explanation are explored.
Export Options
About this article
Cite this article as:
Fridovich Irwin, Superoxide Dismutases: Anti- Versus Pro- Oxidants?, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/187152011795255966
DOI https://dx.doi.org/10.2174/187152011795255966 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lipid-Lowering Drugs Acting at the Level of the Gastrointestinal Tract
Current Pharmaceutical Design The Heme Oxygenase System Selectively Modulates Proteins Implicated in Metabolism, Oxidative Stress and Inflammation in Spontaneously Hypertensive Rats
Current Pharmaceutical Design Clinical Value of Prostacyclin and its Analogs in the Management of Pulmonary Arterial Hypertension
Current Vascular Pharmacology Mutations and Common Polymorphisms in ADAMTS13 and vWF Genes Responsible for Increasing Risk of Thrombosis
Cardiovascular & Hematological Disorders-Drug Targets Editorial from Guest Editor [Hot Topic: Searching for Early Stages in Pathophysiology of Lung Disease: Cell Microenvironment (Guest Editor: Giuseppe Miserocchi)]
Current Respiratory Medicine Reviews Role of ARBs in the Blood Hypertension Therapy and Prevention of Cardiovascular Events
Current Drug Targets Targeting the Sarcolemmal Calcium Pump: A Potential Novel Strategy for the Treatment of Cardiovascular Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Role of Vascular Progenitor Cells in Cardiovascular Disease
Current Pharmaceutical Design Chemistry-based Design of Inhibitors for Carboxypeptidase A
Current Topics in Medicinal Chemistry Inflammatory Cytokines and Atherosclerosis Possible Application for the Gene Therapy
Vascular Disease Prevention (Discontinued) Oral Beclomethasone: A Review of its Use in Inflammatory Bowel Disease
Mini-Reviews in Medicinal Chemistry Stable Angina Pectoris: Current Medical Treatment
Current Pharmaceutical Design Obstetrical Hemorrhage Review
Current Women`s Health Reviews Hypertension in Chronic Kidney Disease: Novel Insights
Current Hypertension Reviews Pyrazolines: A Biological Review
Mini-Reviews in Medicinal Chemistry Vitamin D Supplementation in Diabetic Foot Ulcers: A Current Perspective
Current Diabetes Reviews Dietary Small Molecules and Large-Scale Gene Expression Studies: An Experimental Approach for Understanding their Beneficial Effects on the Development of Malignant and Non-Malignant Proliferative Diseases
Current Medicinal Chemistry Vasotrophic Regulation of Age-Dependent Hypoxic Cerebrovascular Remodeling
Current Vascular Pharmacology Echocardiographic Hemodynamic Monitoring in the Critically Ill Patient
Current Cardiology Reviews Current Therapeutic Drugs Against Cerebral Vasospasm after Subarachnoid Hemorrhage: A Comprehensive Review of Basic and Clinical Studies
Current Drug Delivery