Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Superoxide Dismutases: Anti- Versus Pro- Oxidants?

Author(s): Irwin Fridovich.

Abstract:

The family of superoxide dismutases (SODs) are well known for their antioxidant actions exerted by catalyzing the conversion of O2˙- into H2O2 plus oxygen. The importance of this action is revealed by the multiple phenotypic deficits exhibited by a variety of organisms that have been made to lack one or more of the SODs. Never the less there have been reports of deleterious consequences caused by overproduction of SOD. Several explanations have been proposed for these counter intuitive effects; one of which is that elevated SOD causes increased formation of H2O2. The reasons for dismissing this explanation are explored.

Keywords: Superoxide, Hydrogen peroxide, Superoxide dismutases, Catalases, Peroxidases

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2011
Page: [175 - 177]
Pages: 3
DOI: 10.2174/187152011795255966
Price: $58