Abstract
Tuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drugresistant strains. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria, but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate (EPSP) to chorismate. The aim of this article is to review the available information on chorismate synthase from Mycobacterium tuberculosis.
Keywords: Chorismate synthase, Mycobacterium tuberculosis, shikimate pathway, inhibition, HIV, Genetic products, antiretroviral agents, polypeptide, bacteria, antimycobacterial agents
Current Medicinal Chemistry
Title: Understanding the Structure, Activity and Inhibition of Chorismate Synthase from Mycobacterium tuberculosis
Volume: 18 Issue: 9
Author(s): H. A. Arcuri and M. S. Palma
Affiliation:
Keywords: Chorismate synthase, Mycobacterium tuberculosis, shikimate pathway, inhibition, HIV, Genetic products, antiretroviral agents, polypeptide, bacteria, antimycobacterial agents
Abstract: Tuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drugresistant strains. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria, but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate (EPSP) to chorismate. The aim of this article is to review the available information on chorismate synthase from Mycobacterium tuberculosis.
Export Options
About this article
Cite this article as:
A. Arcuri H. and S. Palma M., Understanding the Structure, Activity and Inhibition of Chorismate Synthase from Mycobacterium tuberculosis, Current Medicinal Chemistry 2011; 18 (9) . https://dx.doi.org/10.2174/092986711795029528
DOI https://dx.doi.org/10.2174/092986711795029528 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synthesis and Anti-onchocercal Activity of Isonicotinoylhydrazones and their Copper(II) and Zinc(II) Complexes
Anti-Infective Agents Potential Inhibitor of Adenylyl Sulfate Reductase Isolated from Desulfovibrio desulfuricans with PU/PU-Ag to Control Pitting Corrosion of Oil Tanks and Pipelines
Current Enzyme Inhibition Perspectives on the Development of Novel Potentially Active Quinolones Against Tuberculosis and Cancer
Mini-Reviews in Medicinal Chemistry A Perspective on Monoamine Oxidase Enzyme as Drug Target: Challenges and Opportunities
Current Drug Targets The Pattern Recognition Receptor Dectin-1: From Fungi to Mycobacteria
Current Drug Targets Opportunities and Challenges in Nano-structure Mediated Drug Delivery: Where Do We Stand?
Current Nanomedicine Maternal Sepsis: Current Approaches to Recognition and Clinical Management
Current Women`s Health Reviews Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens
Current Topics in Medicinal Chemistry The Role of T-Helper Cells in Atherosclerosis
Cardiovascular & Hematological Agents in Medicinal Chemistry Development of Linker-Conjugated Nanosize Lipid Vesicles: A Strategy for Cell Selective Treatment in Breast Cancer
Current Cancer Drug Targets 1,3-Thiazolidin-4-ones: Biological Potential, History, Synthetic Development and Green Methodologies
Current Organic Synthesis 13-lncRNAs Signature to Improve Diagnostic and Prognostic Prediction of Hepatocellular Carcinoma
Combinatorial Chemistry & High Throughput Screening Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase
Combinatorial Chemistry & High Throughput Screening Intracellular Drug Delivery: Mechanisms for Cell Entry
Current Pharmaceutical Design General Theory for Multiple Input-Output Perturbations in Complex Molecular Systems. 1. Linear QSPR Electronegativity Models in Physical, Organic, and Medicinal Chemistry
Current Topics in Medicinal Chemistry In Silico Screening for Potent Inhibitors against the NS3/4A Protease of Hepatitis C Virus
Current Pharmaceutical Design Homology Models in Docking and High-Throughput Docking
Current Topics in Medicinal Chemistry 4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview
Current Topics in Medicinal Chemistry Interaction Mechanisms of Inorganic Nanoparticles and Biomolecular Systems of Microorganisms
Current Chemical Biology The Interplay of Disease Modifying Anti Rheumatic Drugs and Tuberculin Skin Test
Current Reviews in Clinical and Experimental Pharmacology