Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

Author(s): J. C. Borges, C. H.I. Ramos.

Journal Name: Current Medicinal Chemistry

Volume 18 , Issue 9 , 2011

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Abstract:

The interest in analytical ultracentrifugation (AUC) to analyze protein structural parameters and interactions has increased in the past decades as a result of several developments on new generation instrumentation and data analysis tools. In this article, we review AUC principles and applications to study proteins, emphasizing molecular targets of Mycobacterium tuberculosis.

Keywords: Analytical ultracentrifugation, protein folding, Mycobacterium tuberculosis, protein structure-function, anti-tuberculosis agents, high centrifugal force, hydrodynamic parameters, sedimentation, colloids, macromolecules

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Article Details

VOLUME: 18
ISSUE: 9
Year: 2011
Page: [1276 - 1285]
Pages: 10
DOI: 10.2174/092986711795029537
Price: $58

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