Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice

Author(s): E.-J. Shin, J.-M. Kim, X.-K. T. Nguyen, T.-T. L. Nguyen, S. Y. Lee, J.-H. Jung, M. J. Kim, W. K. Whang, K. Yamada, T. Nabeshima, H.-C. Kim.

Journal Name: Current Neuropharmacology

Volume 9 , Issue 1 , 2011

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Abstract:

It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

Keywords: Gastrodia elata Bl, phencyclidine, schizophrenia, 5-HT1A receptors, chronic, devastating, anxiolytic, anti-depressant, anti-convulsant, anti-oxidant, anti-depressant effects

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2011
Page: [247 - 250]
Pages: 4
DOI: 10.2174/157015911795017263

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