Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

Author(s): T. Okochi, T. Kishi, M. Ikeda, T. Kitajima, Y. Kinoshita, K. Kawashima, T. Okumura, T. Tsunoka, Y. Fukuo, T. Inada, M. Yamada, N. Uchimura, M. Iyo, I. Sora, N. Ozaki, H. Ujike, N. Iwata.

Journal Name: Current Neuropharmacology

Volume 9 , Issue 1 , 2011

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Abstract:

Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Keywords: Methamphetamine-induced psychosis, endothelial nitric oxide synthase (NOS3), gene-based case-control association study, endothelial nitric oxide synthase, (NOS3), gene-based case-control association Study, psychiatric disorder, dopaminergic neurotoxicity, schizophrenia, neuronal dysfunction, behavioral abnormality

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2011
Page: [151 - 154]
Pages: 4
DOI: 10.2174/157015911795017119

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