The Pharmacological Management of Intrahepatic Cholestasis of Pregnancy
Francesco Azzaroli, Laura Turco, Andrea Lisotti, Claudio Calvanese and Giuseppe Mazzella
Affiliation: Gastroenterology Unit, St. Orsola-Malpighi Hospitali, Bologna Department of Clinical Medicine, University of Bologna, via Massarenti 9-40138 Bologna, Italy.
Keywords: Bile acids, cholestasis, pregnancy, pruritus, treatment, ursodeoxycholic acid, S-adenosyl-methionine, glucocorticoid therapy, Elevated Liver, Low Platelets, Haemolysis
Intrahepatic cholestasis of pregnancy is the most common liver disease occurring in the second half of pregnancy, characterized by pruritus and elevated serum bile acids often coupled to abnormal liver tests. Maternal prognosis is favourable with a complete symptom resolution after delivery, while preterm deliveries, fetal respiratory distress and stillbirths may occur. The goal of the pharmacological treatment of the disease is to improve maternal symptoms and biochemical alterations and, most importantly, to reduce fetal adverse events. The present manuscript will review the current knowledge on the pharmacological treatment of intrahepatic cholestasis of pregnancy.
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