Abstract
Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids can be problematic as corticosteroids have been shown to promote neutrophil survival which, in turn, accentuates neutrophilic inflammation. In light of such cases, novel targeted medications must be developed that could control neutrophilic inflammation while still maintaining their antibacterial/anti-fungal properties, thus allowing individuals to maintain effective innate immune responses to invading pathogens. The aim of this review is to describe the molecular mechanisms of neutrophil apoptosis and how these pathways are modulated by glucocorticoids. These new findings are of potential clinical value and provide further insight into treatment of neutrophilic inflammation in lung disease.
Keywords: Apoptosis, glucocorticoid, inflammation, neutrophils, airway diseases, infection, caspases, Bcl-2, Dex, asthma, signaling pathway
Current Drug Targets
Title: The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival
Volume: 12 Issue: 4
Author(s): Arash S. Saffar, Heather Ashdown and Abdelilah S. Gounni
Affiliation:
Keywords: Apoptosis, glucocorticoid, inflammation, neutrophils, airway diseases, infection, caspases, Bcl-2, Dex, asthma, signaling pathway
Abstract: Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids can be problematic as corticosteroids have been shown to promote neutrophil survival which, in turn, accentuates neutrophilic inflammation. In light of such cases, novel targeted medications must be developed that could control neutrophilic inflammation while still maintaining their antibacterial/anti-fungal properties, thus allowing individuals to maintain effective innate immune responses to invading pathogens. The aim of this review is to describe the molecular mechanisms of neutrophil apoptosis and how these pathways are modulated by glucocorticoids. These new findings are of potential clinical value and provide further insight into treatment of neutrophilic inflammation in lung disease.
Export Options
About this article
Cite this article as:
S. Saffar Arash, Ashdown Heather and S. Gounni Abdelilah, The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival, Current Drug Targets 2011; 12 (4) . https://dx.doi.org/10.2174/138945011794751555
DOI https://dx.doi.org/10.2174/138945011794751555 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Demystifying the ACE Polymorphism: From Genetics to Biology
Current Pharmaceutical Design B Cells and Beyond: Therapeutic Opportunities Targeting Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) TGF-β: Its Role in Asthma and Therapeutic Potential
Current Drug Targets Nanoscale Formulations and Diagnostics With Their Recent Trends: A Major Focus of Future Nanotechnology
Current Pharmaceutical Design Black Widow Spider (Latrodectus mactans) Antivenom in Clinical Practice
Current Pharmaceutical Biotechnology Phylogeny and Genetic Code: Evolution and Conservation
Current Pharmaceutical Design Development of IL-5 Receptor Antagonists
Current Pharmaceutical Design STAT3 as a Therapeutic Target for Glioblastoma
Anti-Cancer Agents in Medicinal Chemistry Serendipity of Erythromycin in the Management of Periprosthetic Inflammation
Current Drug Therapy Analysis of Trends and Opportunities of Anti-Allergy Patents in China from 1998 to 2008
Recent Patents on Inflammation & Allergy Drug Discovery Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
Current Pharmaceutical Design Optimized Methods for In Vitro and In Vivo Anti-Inflammatory Assays and Its Applications in Herbal and Synthetic Drug Analysis
Mini-Reviews in Medicinal Chemistry Treatment of Viral Encephalitis
Central Nervous System Agents in Medicinal Chemistry Meet Our Editorial Board Member:
Current Drug Metabolism Signal Transduction Therapy with Rationally Designed Kinase Inhibitors
Current Signal Transduction Therapy Chemokine Receptors in Chronic Obstructive Pulmonary Disease (COPD)
Current Drug Targets Hydrogen Sulfide: A New Tool to Design and Develop Drugs
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer
Current Gene Therapy Otitis Media: Epidemiology and Management
Infectious Disorders - Drug Targets Role of Peripheral Tachykinin Receptors in Neurogenic Inflammation of the Respiratory, Genitourinary and Gastrointestinal Systems
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents