Applications of Arterial Spin Labelling in Mild Cognitive Impairment, Alzheimers Disease and Other Forms of Dementia

Author(s): Norbert Schuff.

Journal Name: Current Medical Imaging

Volume 7 , Issue 1 , 2011

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Abstract:

The development of an accurate marker for Alzheimers disease (AD) at the earliest stage is an important public health goal. Modern neuroimaging techniques offer one potential approach to identify a marker for AD. This review focuses on the detection of alterations in brain perfusion as a potentially sensitive index of AD pathology using arterial spin labeling (ASL) perfusion mapping – a relatively new variant of magnetic resonance imaging (MRI). Key findings of ASL perfusion studies in AD mild cognitive impairment (MCI), a transitional stage between normal aging and AD as well as in other forms of dementia are discussed. Furthermore, the value of ASL-MRI for improved diagnosis and prediction of AD is critically reviewed.

Keywords: Magnetic resonance imaging, cerebral blood flow, Alzheimer's disease, mild cognitive impairment, ASL- MRI, CASL, PASL, MCI, PET, FTD

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2011
Page: [73 - 79]
Pages: 7
DOI: 10.2174/157340511794653487

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