Alzheimers disease (AD) is a progressive disease usually accompanied by regional atrophy that can be detected noninvasively using structural magnetic resonance imaging (MRI). An abundant literature has demonstrated the value of quantitative measurements of regional atrophy in AD, suggesting that MR based volumetry and morphometry could be valuable and useful in clinical practice. The aim of this paper is mainly to recall the most critical points to consider when using MRI for automated brain volumetry and morphometry and review briefly the main findings in the literature on brain volumetry and morphometry in AD.
Keywords: Alzheimer's disease, magnetic resonance imaging, morphometric biomarkers, MR-based morphometry, MR-based, volumetry, volumetric biomarkers, mild cognotive impairmentMCI, radio frequency FQ, ADNI, SNR
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