Biocatalytic Transformations of Steroids: Focus on Hydrolase-Catalyzed Reactions

Author(s): M. Manuel Cruz Silva, Joao F. Carvalho, Sergio Riva, M. Luisa Sa e Melo.

Journal Name: Current Organic Chemistry

Volume 15 , Issue 6 , 2011

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Abstract:

Steroids comprise several classes of structurally related molecules with multiple bioactivities. Due to their complexity, the selective modification of these polycyclic compounds is challenging. This review outlines recent developments in the use of biocatalysts for the transformation of steroids, specifically focusing on the synthetic exploitation of hydrolases. Accordingly, several regio- and stereoselective acylations and deacylations mediated by lipases and proteases are discussed en route to preparation of new derivatives with useful application in pharmaceutical and food chemistry.

Keywords: Acylations, hydrolases, lipases, polyhydroxylated compounds, proteases, selectivity, steroids

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Article Details

VOLUME: 15
ISSUE: 6
Year: 2011
Page: [928 - 941]
Pages: 14
DOI: 10.2174/138527211794518871
Price: $58

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