Microwave Assisted Synthesis and Evaluation of Modified Pea Starch as Tablet Superdisintegrant

Author(s): Akhilesh V. Singh, Anudwipa Singh, Lila K. Nath.

Journal Name: Current Drug Delivery

Volume 8 , Issue 2 , 2011

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Abstract:

In the present study, cross linked sodium carboxymethylated pea starch (SCPS) was synthesized and evaluated as tablet superdisintegrant in diclofenac sodium based tablets. SCPS was synthesized using native pea starch with monochloroacetic acid and NaOH in microwave radiation environment. Finally the dried product was cross-linked with phosphorous oxychloride, which produced granular highly swellable starch. SCPS with degree of substitution of 0.34 was formed and it was further evaluated as superdisintegrant in diclofenac sodium based tablets. Diclofenac sodium tablets were prepared by direct compression method with 2, 4, 6 and 8%w/w of SCPS as superdisintegrant and further comparatively evaluated for in vitro disintegration and dissolution study with Sodium starch glycolate containing tablets as reference. The results revealed that SCPS could be a promising superdisintegrant for immediate release tablets in concentration dependant manner.

Keywords: Carboxymethylation, cross-linking, superdisintegrant, pea starch, diclofenac, sodium

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2011
Page: [203 - 207]
Pages: 5
DOI: 10.2174/156720111794479853
Price: $58

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