Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

Author(s): Scott S. Woodard, Kevin D. Jerome.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 14 , Issue 2 , 2011

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Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles.

Keywords: Cyclizations, combinatorial chemistry, 1,2,4-triazoles, Pinner reaction, hydrazides, imidates, Amberlyst A-21, Methyl imidate HCl, Benzyl imidate, acetonitrile, H NMR, Isovaleroic hydrazide

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Article Details

Year: 2011
Page: [132 - 137]
Pages: 6
DOI: 10.2174/138620711794474033
Price: $58

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