A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.
Keywords: Aminothiazole, combinatorial chemistry, solution phase synthesis, automation, Alzheimer's disease, chronic pain, Huntington's disease, Chemspeed ASW 2000 automated, triethylamine, H NMR spectroscopy, DMF
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