Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up

Author(s): Hans-Peter Buchstaller, Uwe Anlauf.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 14 , Issue 2 , 2011

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A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.

Keywords: Aminothiazole, combinatorial chemistry, solution phase synthesis, automation, Alzheimer's disease, chronic pain, Huntington's disease, Chemspeed ASW 2000 automated, triethylamine, H NMR spectroscopy, DMF

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Article Details

Year: 2011
Page: [104 - 108]
Pages: 5
DOI: 10.2174/138620711794474024
Price: $58

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