Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex


Mechanisms of Drug Resistance to Vascular Endothelial Growth Factor (VEGF) Inhibitors

Author(s): Jahan Tavakoli, Jeanny B. Aragon-Ching.


Angiogenesis inhibitors have a major role in the treatment of varying cancers today. While originally thought to be independent of resistance, increasing data suggests varying mechanisms that bring about drug resistance, either intrinsically or through adaptation. The role of vascular endothelial growth factor single nucleotide polymorphisms (VEGF SNPs) in terms of therapeutic response and toxicity has increasingly been recognized, as well as its potential for contributing to drug resistance. This review will focus on theories, preclinical models, and clinical trials that help elucidate the mechanisms of resistance and clinical response to angiogenesis inhibitors.

Keywords: Angiogenesis, angiogenesis inhibitors, polymorphisms, drug resistance, toxicity

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Article Details

Year: 2010
Page: [593 - 600]
Pages: 8
DOI: 10.2174/187152010794473948
Price: $58