Microwave-Assisted Chemistry of 2(1H)-pyrazinones

Author(s): Vaibhav P. Mehta, Prasad Appukkuttan, Erik Van der Eycken.

Journal Name: Current Organic Chemistry

Volume 15 , Issue 2 , 2011

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Abstract:

The application of microwave irradiation for the synthesis and decoration of the 2(1H)-pyrazinone scaffold as well as for the synthesis of various heterocycles starting from this core structure has been reviewed.

Keywords: Microwave irradiation, Pyrazinone, Cross-coupling, Simultaneous cooling, Diels-Alder reaction, CuAAC, Suzuki coupling, Heck coupling, Sonogashira coupling, Stille coupling, Liebeskind-Srogl coupling, Buchwald-Hartwig coupling, heterocyclic compounds, cycloaddition-elimination reactions, non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs), Microwave-Assisted Organic Synthesis (MAOS), trimethylsilylcyanide (TMS-cyanide), dimethoxyethane (DME), oxalyl chloride, arthritis, asthma, depression, heterogeneous gas-phase catalytic reactions, Paar multimode microwave apparatus, bis-lactams, 1,3-dimethyl acetylenedicarboxylate (DMAD), retro-Diels-Alder fragmentation, Tumor Necrosis Factor (TNF), arachidonic acid, collageninduced platelet aggregation, pyrazinonetriazoles, olefins, acetylenes, microwave-assisted transition-metal-mediated reactions, Sn-reagents, bis-reduction, Heck-product, microwave-assisted homo-dimerization reaction, bis(pinacolato)diboron, microwave-assisted desulfitative Sonogashira-type cross-coupling, Desulfitative C3-Dimethylamination, microwave-assisted cascade reaction, Arbuzov-type reaction, glycosyl-azides, glycopeptidomimetics, I2-Mediated Electrophilic Cyclization, nucleoside, D-ribose, 2-deoxy-D-ribose, hitherto unknown nucleoside, Buchwald-Hartwig type intramolecular cyclization, Lawesson's reagent, transition-metal-catalyzed cross-coupling reaction, benzylic halides, toxic stannanes, arylboronic acids, Cu(II)-mediated Liebeskind-Srogl reaction, 2(1H)-pyrazinone scaffold, copper(I)-thiophene carboxylate (CuTC), solid phase organic synthesis (SPOS), microwave-assisted solid-phase chemistry, Wang amide resin, microwave-assisted Cucatalyzed Ullmann coupling, HIV replication, traceless-linkage, Merrifield resin, alkynyloxy, imidoylchloride

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2011
Page: [265 - 283]
Pages: 19
DOI: 10.2174/138527211793979790
Price: $58

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