Homocysteine, Cardiovascular Inflammation, and Myocardial Remodeling

Author(s): Jennifer M. Finch, Jacob Joseph.

Journal Name:Cardiovascular & Hematological Disorders-Drug Targets

Volume 10 , Issue 4 , 2010

Abstract:

Chronic heart failure is a major public health problem causing considerable morbidity and mortality. Recent studies have shown that an elevated plasma level of homocysteine is a strong independent risk factor for heart failure, in addition to atherosclerotic disease. Preclinical studies have demonstrated that induced hyperhomocysteinemia acts via multiple pathogenic mechanisms, including inflammation and oxidative stress, to promote adverse cardiac remodeling and failure. However, clinical studies have not conclusively shown a causative relation between hyperhomocysteinemia and cardiovascular disease. This article will review current data concerning homocysteine and its pathogenic relationship to heart failure.

Keywords: Homocysteine, Heart Failure, Remodeling, Cardiovascular Disease, morbidity, mortality, atherosclerotic disease, oxidative stress, atherothrombotic, spironolactone, hypertension, diabetes mellitus, obesity, B-type, natriuretic peptide, hyperuricaemia, echocardiographic signs, diastolic diameter, methionine, cystathionine, methyltetrahydrofolate, adenosylmethionine, neurohormonal model, angiotensin-converting enzyme, fibrosis, tumor necrosis, myocardium, Interleukins-1, matrix metalloproteinases, Cathepsin G, anti-oxidant vitamin, Coronary artery disease

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2010
Page: [241 - 245]
Pages: 5
DOI: 10.2174/187152910793743887
Price: $58