Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Vitamin D Supplementation: A Promising Approach for the Prevention and Treatment of Strokes

Author(s): Stefan Pilz, Andreas Tomaschitz, Christiane Drechsler, Armin Zittermann, Jacqueline M. Dekker and Winfried Marz

Affiliation: Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.


Vitamin D deficiency is highly prevalent due to lifestyle and environmental factors which limit sunlight induced vitamin D production in the skin. This “pandemic” of vitamin D deficiency is of concern because low levels of 25-hydroxyvitamin D (25[OH]D) have been associated with cardiovascular, musculoskeletal, infectious, autoimmune and malignant diseases. Epidemiological studies have largely but not consistently shown that vitamin D deficiency is a risk factor for strokes. This is supported by associations of low 25(OH)D levels with cerebrovascular risk factors, in particular with arterial hypertension. Vitamin D has also been shown to exert neuroprotective, neuromuscular and osteoprotective effects which may reduce cognitive and functional impairments in poststroke patients. Hence, the current literature favours the notion that vitamin D supplementation is a promising approach for the prevention and treatment of strokes but accurate data from interventional studies are missing. Randomized controlled trials are therefore urgently needed to evaluate whether vitamin D supplementation reduces the incidence of strokes and improves the outcome of poststroke patients. We do, however, believe that currently published data on the multiple health benefits of vitamin D and the easy safe and inexpensive way by which it can be supplemented already argue for the prevention and treatment of vitamin D deficiency in order to reduce stroke associated morbidity and mortality.

Keywords: Cardiovascular, cerebrovascular, cognitive, neuromuscular, vitamin D, stroke, 25-hydroxyvitamin D, 25(OH)D, calcitriol, parathyroid hormone, PTH, vitamin D deficiency, hypercalcemia, Arterial Hypertension, Metabolic Syndrome, dyslipidemia, atorvastatin, Atherosclerosis, vascular smooth muscle cells, VSMC, thrombogram, Hyperparathyroidism, Inflammation, LURIC, hemorrhagic stroke, ischemic stroke, glial cell linederived neurotrophic factor (GDNF), L-VSCCs, Osteoporosis

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Article Details

Page: [88 - 96]
Pages: 9
DOI: 10.2174/138945011793591563