Role of Epigenetic Regulatory Mechanisms in the Mechanism of Essential Hypertension

Zhong      Guang-Wei; Luo      Yan-Hong; Li      Wei; Zhong      Chang-Gao; Zhang      Cheng

Abstract

Hypertension is among the common and leading causes of morbidity and mortality throughout the globe. The biological process of hypertension involves multiple physiological pathways, each of which may be affected by multiple gene products. But the mechanisms under this difference are still not full understood. In recent years, some evidence has been found supporting the involvement of epigenetic mechanisms in many cardiovascular diseases and others. We hypothesised that epigenetic mechanisms have been also involved in essential hypertension possibly by suppression of and changing the relational genes with essential hypertension.

Keywords: Epigenetic mechanisms, Essential hypertension, DNA methylation, Hypertension, cardiovascular diseases, obesity, diabe-tes, hyperlipidemia, Epigenetics, DNA, histone code, DNA methyl-transferases, methyl-CpG binding proteins, insulator pro-teins, histone-modifying enzymes, chromatin-remodelling complexes, cancer, autoimmune disorders, CpG, Estrogen receptor expression, DNA methyltrans-ferase, histone deacetylase inhibition, AT1b gene, 11b-HSD2(HSD11B2), sodium retention, hypokalaemia, 11 beta-hydroxysteroid dehydrogenase 2, tetrahydrocortisone-metabolites, HSD11B2, 5-aza-2-deoxycytidine, procainamide, endo-thelin-converting enzyme, 5-AZA-CdR acti-vates, methylated b1-AR gene promoter, H9c2 myocar-dial, antihypertensive response, SERPINA3, Smoking, Mito-fusin-2, Ras inhibitor, anti-proliferative effects, hypermethylation, Mfn-2