Current Hypertension Reviews

Prof. Kazuomi Kario
Jichi Medical University
School of Medicine
Tochigi
Japan

Back

Role of Epigenetic Regulatory Mechanisms in the Mechanism of Essential Hypertension

Author(s): Zhong Guang-Wei, Luo Yan-Hong, Li Wei, Zhong Chang-Gao, Zhang Cheng.

Abstract:

Hypertension is among the common and leading causes of morbidity and mortality throughout the globe. The biological process of hypertension involves multiple physiological pathways, each of which may be affected by multiple gene products. But the mechanisms under this difference are still not full understood. In recent years, some evidence has been found supporting the involvement of epigenetic mechanisms in many cardiovascular diseases and others. We hypothesised that epigenetic mechanisms have been also involved in essential hypertension possibly by suppression of and changing the relational genes with essential hypertension.

Keywords: Epigenetic mechanisms, Essential hypertension, DNA methylation, Hypertension, cardiovascular diseases, obesity, diabe-tes, hyperlipidemia, Epigenetics, DNA, histone code, DNA methyl-transferases, methyl-CpG binding proteins, insulator pro-teins, histone-modifying enzymes, chromatin-remodelling complexes, cancer, autoimmune disorders, CpG, Estrogen receptor expression, DNA methyltrans-ferase, histone deacetylase inhibition, AT1b gene, 11b-HSD2(HSD11B2), sodium retention, hypokalaemia, 11 beta-hydroxysteroid dehydrogenase 2, tetrahydrocortisone-metabolites, HSD11B2, 5-aza-2-deoxycytidine, procainamide, endo-thelin-converting enzyme, 5-AZA-CdR acti-vates, methylated b1-AR gene promoter, H9c2 myocar-dial, antihypertensive response, SERPINA3, Smoking, Mito-fusin-2, Ras inhibitor, anti-proliferative effects, hypermethylation, Mfn-2

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 6
ISSUE: 4
Year: 2010
Page: [282 - 284]
Pages: 3
DOI: 10.2174/157340210793611686
Price: $58