Contribution of Inflammation to Fat Redistribution and Metabolic Disturbances in HIV-1 Infected Patients

Author(s): Metodi V. Stankov , Georg M.N. Behrens .

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 30 , 2010


Antiretroviral therapy (ART) has significantly reduced the morbidity and mortality of patients infected with the human immunodeficiency virus 1 (HIV-1). In a significant number of patients, ART is associated with fat redistribution and metabolic alterations such as dyslipidemia, insulin resistance (IR) and type 2 diabetes, summarized under the term HIV-associated lipodystrophy syndrome (HIVLS). The pathogenesis of HIV-LS is complex and involves a number of factors including ART, HIV-1, abnormal fat redistribution, metabolic abnormalities and chronic inflammation. In view of a novel understanding on how chronic inflammation contributes to the pathogenesis of HIV-1 infection, this review focuses on the interaction of the immune system and metabolic pathways and the potential consequences for the HIV-LS. Based on the current literature, we suggest a central role of systemic inflammation in triggering and deteriorating various components of the HIV-LS.

Keywords: Antiretroviral therapy, HIV-1, fat redistribution, metabolic syndrome, chronic inflammation

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Article Details

Year: 2010
Page: [3361 - 3371]
Pages: 11
DOI: 10.2174/138161210793563473
Price: $58

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PDF: 12