Patent Foramen Ovale and Thromboembolic Complications

Author(s): Giovanni Fazio, Giovanni Ferro, Giuseppe Barbaro, Kalil Fattouch, Filippo Ferrara, Giuseppina Novo, Salvatore Novo.

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 31 , 2010

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Abstract:

The foramen ovale, an atrial septal defect, which is essential in the fetal circulation, remains patent through adulthood in approximately 25% of the general population and therefore it represents the most common persistent abnormality of fetal origin. Patent foramen ovale (PFO) allows interatrial right-to-left blood shunting during those periods of the cardiac cycle in which the right atrial pressure exceeds the left one. An increasing number of pathological manifestations of PFO has been recently identified; among these, paradoxical systemic embolism, refractory hypoxemia in patients with right ventricular myocardium infarction or severe pulmonary disease, orthostatic oxygen desaturation in the rare platypnea-orthodeoxia syndrome, neurological decompression illness in divers, high altitude pilots and astronauts, and finally, migraine headache with aura. Nowadays, many techniques allow to detect a PFO. In this study, we investigated each of them, assessing their potential diagnostic role even in comparison with the main features of the other methods.

Keywords: Patent foramen ovale, diagnostic methods, three dimensional echocardiography, Thromboembolic Complications, atrial septal defect, fetal circulation, cardiac cycle, refractory hypoxemia, ventricular myocardium, paradoxical systemic embolism, pulmonary disease, orthostatic oxygen desatura-tion, platypnea-orthodeoxia syndrome, migraine headache, interatrial fetal septa, septum primum, septum secundum, cryptoge-netic, orthostatic oxygen, dyspnea, cryptogenetic strokes, interatrial septum aneurism, cryp-togenetic ictus, microischemia, TRANSTHORACIC ECHOCARDIOGRAPHY, doppler ve-locimetric method, TRANSCRANIC ULTRASONOGRAPHY, transesophageal ecocardiography's one, Valsalva maneuver, CONTRAST ECHOCARDIOGRAPHY, COMPUTED TOMOGRAPHY (TC), NUCLEAR MAGNETIC RESONANCE (NMR)

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Article Details

VOLUME: 16
ISSUE: 31
Year: 2010
Page: [3497 - 3502]
Pages: 6
DOI: 10.2174/138161210793563310
Price: $58

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