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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Mn-SOD and Chronic Inflammation of Gastric Mucosa

Author(s): J. Dovhanj, D. Svagelj, M. Smolic, R. Smolic and I. Maric

Volume 9, Issue 4, 2010

Page: [347 - 354] Pages: 8

DOI: 10.2174/1871523011009040347

Price: $65

Abstract

The involvement of reactive oxygen species in the inflammatory tissue destruction is well known. Significant changes in the activity and expression of several isoforms of superoxide dismutase were observed in the human gastric disease. Mn-SOD attracted the attention of researchers because of its inducibility by oxidative stress. There is increasing evidence that oxidative stress plays a role in the progression of mucosal damage leading to gastric cancer. The evaluation of possible modulation of Mn-SOD activity during chronic inflammation of gastric mucosa could reveal whether its assessment is important to prevent the accumulation of gastric epithelial cell damage and thereby reduce the risk of gastric carcinoma.

Keywords: Free radical, gastric mucosa, inflammation, oxidative stress, ROS, SOD.


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