Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Mn-SOD and Chronic Inflammation of Gastric Mucosa

Author(s): J. Dovhanj, D. Svagelj, M. Smolic, R. Smolic, I. Maric.

Abstract:

The involvement of reactive oxygen species in the inflammatory tissue destruction is well known. Significant changes in the activity and expression of several isoforms of superoxide dismutase were observed in the human gastric disease. Mn-SOD attracted the attention of researchers because of its inducibility by oxidative stress. There is increasing evidence that oxidative stress plays a role in the progression of mucosal damage leading to gastric cancer. The evaluation of possible modulation of Mn-SOD activity during chronic inflammation of gastric mucosa could reveal whether its assessment is important to prevent the accumulation of gastric epithelial cell damage and thereby reduce the risk of gastric carcinoma.

Keywords: Free radical, gastric mucosa, inflammation, oxidative stress, ROS, SOD, reactive oxygen species, gastric cancer, peptic ulcer, malignancy, Helicobacter pylori, superoxide dismutase (SOD), cytosolic Cu, mitochondrial Mn-SOD, cardiomyopathy, neurodegeneration, tumor metastasis, angiogenesis, chemotherapy agents, stimuli, dysplasia, esophageal adenocarcinoma, esophagealadenocarcinoma, nicotinamide adenine dinucleotide phosphate (NAD(P)H), nitric oxide synthase, nitrotyrosine, chemiluminescence assay, reperfusion injury, neurologic disorders, immunogenicity, pyran copolymer-SOD, immunomodulator, Manganese superoxide dismutase, Copper,zinc superoxide dismutase, Extracellular superoxide dismutase, Peroxynitrite, Nitrogen dioxide, Adenosine triphosphate

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2010
Page: [347 - 354]
Pages: 8
DOI: 10.2174/1871523011009040347
Price: $58