Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Role of Alpha-1 Antitrypsin (AAT) in Ocular Allergy and Uveitis

Author(s): Andrea Leonardi, Francesca Urban, Massimo Bortolotti.

Abstract:

Ocular allergy and uveitis are varied groups of inflammatory eye disorders characterized by complex and as yet ill-defined pathogeneses. Alpha-1 antitrypsin (AAT) is the archetype of the serine protease inhibitor supergene family. AAT deficiency is one of many factors that may be involved in abnormalities such as liver and lung disease, inflammatory joint diseases, and inflammatory eye diseases. In the present review, the role played by AAT in ocular inflammation is analyzed, particularly in vernal keratoconjunctivitis (VKC) and uveitis. Tear trypsin inhibitory capacity was shown to be reduced in VKC patients. In uveitis patients, a significant difference in AAT phenotypes was found compared to normal subjects. We propose that a reduced inhibitory capacity of ATT and AAT might facilitate or prolong different types of ocular inflammation.

Keywords: Ocular allergy, uveitis, alpha-1-antitrypsin deficiency, vernal keratoconjunctivitis, HLA-B27 typing, Alpha-1 antitrypsin (AAT), serine protease, rhinitis, perennial allergic conjunctivitis (PAC), atopic keratoconjunctivitis (AKC), giant papillary conjunctivitis, atopic keratoconjunctivitis, Behçet's disease, juvenile idiopathic arthritis, histamine, anaphylactoid reactions, neovascularization, pseudogerontoxon, keratoconus, limbal tissue hyperplasia, staphylococcus aureus, interleukin, phenylephrine, interferon-gamma, tumor necrosis factor, matrix metalloproteinases, adrenergic receptors, VKC tissues, antigen presenting cells (APC), sarcoidosis, retinal pigment epithelium, toxoplasmosis, bartonellosis, Lyme disease, spondyloarthropathies, alpha-1-antichymotrypsin, alpha-2-macroglobulin, lactoferrin, arachidonic acid, peroxynitrite anion, Tumor necrosis factor-alfa, Metalloproteinases, Eosinophil cationic protein, Fluorescence units, Plasminogen activator inhibitor

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2010
Page: [304 - 313]
Pages: 10
DOI: 10.2174/1871523011009040304
Price: $58