The Role of Alpha1-Antitrypsin Deficiency in Respiratory Disease

Author(s): Noor Kalsheker.

Journal Name:Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 9 , Issue 4 , 2010


The main aim of this review is to describe the role of alpha1-antitrypsin deficiency (AATD) in respiratory disease which accounts for over 50% of AATD associated deaths. Only about 10% of all patients with AATD are detected and the majority of cases go undetected or are asymptomatic. Cigarette smoking and other environmental exposures are important triggers for developing respiratory disease. This review examines the spectrum of respiratory manifestations of AATD, the epidemiology of AATD worldwide, the molecular pathophysiology underlying the respiratory component and the role of augmentation therapy in AATD related disease.

Keywords: Antitrypsin deficiency, respiratory disease, molecular pathology, therapy, alpha1-antitrypsin deficiency (AATD), Chronic obstructive pulmonary disease (COPD), emphysema, hyperinflation, Protease inhibitor (Pi), chronic bronchitis, asthma, forced expiratory, volume in one second (FEV1), bronchiectasis, symptomatic disease, immunisation, dexamethasone, Pi Mmalton, Pi Msiiyama, neutrophil elastase, bronchoalveolar, Alpha1-antitrypsin deficiency, Chronic obstructive pulmonary disease, Forced Expiratory Volume in one second, Protease inhibitor, United States of America

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Article Details

Year: 2010
Page: [299 - 303]
Pages: 5
DOI: 10.2174/1871523011009040299
Price: $58