Abstract
Diabetes mellitus, an epidemic metabolic disorders characterized by high blood glucose level associated with various macrovascular and microvascular complications, is one of the main causes of human suffering across the globe. Researchers around the world mainly focused on insulin, insulin analogues, oral hypoglycemic agents and various other complementary and alternate medicines to control the blood glucose levels in diabetes. The present review summarizes the disorders associated with elevation of blood glucose level, biochemical & endocrinological aspects and the current strategies to control. The emphasis has been laid in particular on the new potential biological targets and the possible treatment as well as the current ongoing research status on new generation hypoglycemic agents.
Keywords: Diabetes, insulin, carbohydrate metabolism, sulfonylurea, thiazolidindione, carbohydrate, lipids, lipoprotein, hyperglycemia, nephropathy, retinopathy, neuropathy, T1DM, T2DM, GDM, Cystic Fibrosis, Cushing's syndrome, MHC, TH, NK, CD8, CD4, Genetic Factors, Down's syndrome, fibrinolysis, free fatty acids, glucose, Lipid Metabolism, ketone bodies, VLDL, Glucagon, Catecholamines, Growth Hormone, Glucocorticoids, DNA, Cytokines, NOS, KATP, SUR, ATP, Biguanides, Meglitinide Analogues, Thiazolidindiones, Ocimum santum, antioxidant activity, Allicin, Leucodelphinidine, Charantin, Bumelia sartorum, glycogenolysis, PPAR, GLP-1, LA, IKK, Mifepristone, DPP IV, Amylin Analog, PTP 1B, PTPase, OBA, TC-PTP
Current Medicinal Chemistry
Title: Pharmacology and Chemistry of Diabetes mellitus and Antidiabetic Drugs: A Critical Review
Volume: 17 Issue: 35
Author(s): Ganesh R. Kokil, Prarthana V. Rewatkar, Arunima Verma, Suresh Thareja and Suresh R. Naik
Affiliation:
Keywords: Diabetes, insulin, carbohydrate metabolism, sulfonylurea, thiazolidindione, carbohydrate, lipids, lipoprotein, hyperglycemia, nephropathy, retinopathy, neuropathy, T1DM, T2DM, GDM, Cystic Fibrosis, Cushing's syndrome, MHC, TH, NK, CD8, CD4, Genetic Factors, Down's syndrome, fibrinolysis, free fatty acids, glucose, Lipid Metabolism, ketone bodies, VLDL, Glucagon, Catecholamines, Growth Hormone, Glucocorticoids, DNA, Cytokines, NOS, KATP, SUR, ATP, Biguanides, Meglitinide Analogues, Thiazolidindiones, Ocimum santum, antioxidant activity, Allicin, Leucodelphinidine, Charantin, Bumelia sartorum, glycogenolysis, PPAR, GLP-1, LA, IKK, Mifepristone, DPP IV, Amylin Analog, PTP 1B, PTPase, OBA, TC-PTP
Abstract: Diabetes mellitus, an epidemic metabolic disorders characterized by high blood glucose level associated with various macrovascular and microvascular complications, is one of the main causes of human suffering across the globe. Researchers around the world mainly focused on insulin, insulin analogues, oral hypoglycemic agents and various other complementary and alternate medicines to control the blood glucose levels in diabetes. The present review summarizes the disorders associated with elevation of blood glucose level, biochemical & endocrinological aspects and the current strategies to control. The emphasis has been laid in particular on the new potential biological targets and the possible treatment as well as the current ongoing research status on new generation hypoglycemic agents.
Export Options
About this article
Cite this article as:
R. Kokil Ganesh, V. Rewatkar Prarthana, Verma Arunima, Thareja Suresh and R. Naik Suresh, Pharmacology and Chemistry of Diabetes mellitus and Antidiabetic Drugs: A Critical Review, Current Medicinal Chemistry 2010; 17 (35) . https://dx.doi.org/10.2174/092986710793361225
DOI https://dx.doi.org/10.2174/092986710793361225 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Fluid and Electrolyte Disorders in the Newborn: Sodium and Potassium
Current Pediatric Reviews Adipose Tissue as a Regulator of Energy Balance
Current Drug Targets Atypical Presentation of Tardive Dyskinesia Associated with Risperidone Long-Acting Injection as Maintenance Treatment in Bipolar Affective Disorder: A Case Report
Current Drug Safety Editorial
Current Diabetes Reviews Ovalbumin Induced Allergic Rhinitis and Development of Prediabetes to Rats: Possible Role of Th2 Cytokines
Inflammation & Allergy - Drug Targets (Discontinued) Appropriate Application of Evidence to the Care of Elderly Patients with Diabetes
Current Diabetes Reviews Inflammation-Induced Thrombosis: Mechanisms, Disease Associations and Management
Current Pharmaceutical Design Central Retinal Vein Occlusion: Current Therapeutic Approach
Vascular Disease Prevention (Discontinued) Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer's Disease
Current Topics in Medicinal Chemistry Properties of the Mesenchymal Endometriotic Stem Cell in the Context of the Immune System and Analysis of its Role in Endometriosis
Recent Patents on Regenerative Medicine A Nanotechnological Approach to the Management of Alzheimer Disease and Type 2 Diabetes
CNS & Neurological Disorders - Drug Targets Editorial (Thematic Issue: Medicinal Chemistry: Neurological and Endocrinological Disorders)
Medicinal Chemistry Diabetes Exacerbates Nanoparticles Induced Brain Pathology
CNS & Neurological Disorders - Drug Targets The Use of Stem Cells in Regenerative Medicine for Parkinson’s and Huntington’s Diseases
Current Medicinal Chemistry Cardiovascular Effects of Glucagon-Like Peptide 1
Mini-Reviews in Medicinal Chemistry Link between Metabolic Syndrome and Insulin Resistance
Current Vascular Pharmacology Diabetic Retinopathy, Superoxide Damage and Antioxidants
Current Pharmaceutical Biotechnology Solid Phase Micro Membrane Tip Extraction and Capillary Electrophoresis of Metformin in Urine Samples
Current Pharmaceutical Analysis The Impact of Diabetes on Adolescent Development: The Experiences of Teenagers with Diabetes Attending a Summer Camp
Adolescent Psychiatry The Science of Hypoglycemia in Patients with Diabetes
Current Diabetes Reviews