Epitope Discovery and Their Use in Peptide Based Vaccines

Author(s): Nadine L. Dudek, Patrick Perlmutter, Marie- Isabel Aguilar, Nathan P. Croft, Anthony W. Purcell.

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 28 , 2010

Abstract:

With recent advances in the design and delivery of peptide-based therapeutics there has been a growing interest in the use of peptides in vaccine design. Moreover, functional dissection and proteomic analysis of the immunogenic epitopes of proteins from pathogenic micro-organisms, cancers and self-tissues targeted by autoimmune responses, have broadened the range of target epitopes and given clues to enhancing peptide immunogenicity. Consistent with these observations; peptides can be synthesised with defined chemical modifications to mimic natural epitopes and/or deliberately introduce protease resistant peptide bonds to regulate their processing independent of tissue specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer and review recent developments in the field of epitope discovery and peptide-based vaccines.

Keywords: Major Histocompatibility Complex, peptide epitope, antigen processing, epitope discovery, epitope validation

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 28
Year: 2010
Page: [3149 - 3157]
Pages: 9
DOI: 10.2174/138161210793292447
Price: $58

Article Metrics

PDF: 36