Bcl-2 Family Proteins as Therapeutic Targets

Author(s): Peter E. Czabotar , Guillaume Lessene .

Journal Name: Current Pharmaceutical Design

Volume 16 , Issue 28 , 2010


The mitochondrion provides the stage for the interplay of molecular interactions that regulate apoptosis via the intrinsic pathway. The release of apoptogenic factors from this compartment constitutes a critical juncture in this apoptotic pathway. Regulation of the integrity of the outer mitochondrial membrane (OMM) is the task of the Bcl-2 family of proteins. A network of interactions between the various subgroups of the family decides the apoptotic fate of a cell and, as such, an imbalance within this network can lead to a variety of disease states. In particular, over-expression of pro-survival Bcl-2 family proteins is a hallmark of many cancers. Here we discuss recent advances in targeting the Bcl-2 family with both peptides and small molecules.

Keywords: Apoptosis, Bcl-2

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Article Details

Year: 2010
Page: [3132 - 3148]
Pages: 17
DOI: 10.2174/138161210793292429
Price: $58

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