Cardiovascular & Hematological Disorders-Drug Targets

(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Garry X. Shen  
University of Manitoba
Winnipeg, MB
Canada

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New Insight in Antiplatelet Therapy Monitoring in Cardiovascular Patients: From Aspirin to Thienopyridine

Author(s): N. Hezard, A. Tessier-Marteau, L. Macchi.

Abstract:

Antiplatelet therapy is used to reduce the risk of ischemic events in patients with cardiovascular disease. The balance of benefits and risks of antiplatelet drugs in cardiovascular disease has been evaluated in large-scale randomised trials, however the absolute benefit for an individual patient and a specific platelet-active drug needs further evaluation. Several well-conducted studies have demonstrated a substantial inter-individual variability in platelet responsiveness to drugs. The historical “gold standard” test of platelet function (optical aggregation) has been extensively used for measuring the effect of antiplatelet drugs, but has limitations. New tests developed (i.e. PFA-100®, VerifyNow®) may overcome some of these limitations but they do not correlate well with each other. Despite these unresolved methodological questions, several recent clinical studies, but not all, suggest a significant correlation between antiplatelet resistance status and serious vascular events. In these conditions, laboratory monitoring for antiplatelet therapies raises several questions: (i) the necessity of a consensus regarding the definition of resistance and the relevant test, (ii) the demonstration that biological resistance has clinical significance, and (iii) the clinical impact of individually adjusting the antiplatelet therapy. Therefore, it is not currently appropriate to test patients or to change therapy on the basis of such tests, other than in prospective and adequately powered clinical trials.

Keywords: Aspirin, clopidogrel, cardiovascular disease, platelet function tests, anti-P2Y12 inhibitors, plate-let aggregometry, modified thromboelastography, semi-automated platelet function tests, platelet function analyser PFA-100®, VerifyNowa® system, flow cytometry, Light/optical transmission aggregometry, LTA, thromboxane A2, TxA2, adenosine diphosphate, ADP, thrombin receptor-activating peptide, TRAP, Multielectrode platelet aggregometry, MEA, stent thrombosis, ST, Ultegra Rapid Platelet Function Assay, plasma von Wille-brand factor, vWF, Platelet Aggregation Unit, PAU, CPA, Vasodilator-stimulated phos-phoprotein, VASP, reticulated platelets, RP, mature Platelet Fraction, IPF, clopidogrel resistance, ANTI-P2Y12, prasugrel, ticagrelor, cangrelor, elinogrel

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2010
Page: [224 - 233]
Pages: 10
DOI: 10.2174/1871529X11006030224
Price: $58