Cardiovascular & Hematological Disorders-Drug Targets

(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Garry X. Shen  
University of Manitoba
Winnipeg, MB


Resident and Non-Resident Stem Cells in Acute Myocardial Infarction

Author(s): Noela Rodriguez-Losada, Manuel F. Jimenez-Navarro, Borja Fernandez, Carmen Rueda-Martinez, Antonia Aranega, Juan A. Marchal, Eduardo de Teresa Galvan.


Cardiovascular disease is the leading cause of death in developed countries. Acute myocardial infarction (AMI) is the result of hypoxia leading to cardiomyocyte death. This causes loss of function of contractile tissue, which is replaced by non-contractile fibrous tissue affecting left ventricular ejection fraction (LVEF).

One of the current approaches to recover LVEF after an AMI is focused on the search for functional cells to replace the dead tissue, via implantation in the heart of autologous progenitor cells with a regenerative capacity. This review classifies these cells into two types: a) non-resident cells and b) resident cells within the cardiac tissue. We provide an overall view of the various subpopulations and their markers, based, in humans and animal models from the early pioneering work to the latest findings.

Keywords: Resident stem cells, cardiovascular disease, endothelial progenitor cells, acute myocardial infarction, left ventricular ejection fraction, LVEF, Ischemic heart disease, IHD, EPC, bone marrow derived mesenchymal stem cells, MSC, ESCs, KDR+ cells, BMDCs, endothelial outgrowth cells, EOC, haematopoietic stem/progenitor cells, HPCs, Very small embryonic-like stem cells, VSEL, Stroma-Vascular Fraction, Skeletal Myoblast, ISL1+ Postnatal Cell, Stem Cell Antigen 1, CDCs, cKIT+ Cardiospheres, Vascular Progenitor Cells, Epicardially-derived cells, myocyte progenitor cells, MPCs

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Article Details

Year: 2010
Page: [202 - 215]
Pages: 14
DOI: 10.2174/1871529X11006030202
Price: $58