Abstract
Apoptosis plays an essential role in the processes of eukaryotic cellular homeostasis, and is thought to be a contributing factor in the development of a variety of pathologies including cancer. Knowledge of the molecular mechanisms and mediators of apoptosis, coupled with the fact that many current anticancer therapies function by activating apoptosis, has led to realization that apoptotic processes not only serve as the crucial regulators of carcinogenesis but are also critical determinants in therapy responses. Defects in apoptosis signaling often lead to ineffective response to anti-cancer therapeutics in the clinic and contribute to development of drug-resistant phenotype. The mediators of apoptosis, therefore, are attractive and rational targets for design and development of apoptosis-promoting strategies to combat cancer. Here we present an overview of different approaches and proof-of-principle evidence for identification, development, and use of agents that target apoptosis signaling in cancer. A synopsis of different apoptosis pathways and the agents, currently in the clinic or in development pipeline, that target mediators of apoptosis is presented. Last, but not least, novel and emerging apoptosis signaling targets with potential utility in anti-cancer drug development are also discussed.
Keywords: Apoptosis, Caspases, p53, IAPs, Mitochondria, Nur77, CARP-1.
Current Cancer Therapy Reviews
Title:Recent Advances and Approaches in Targeting Apoptosis Signaling Pathways for Anti-Cancer Therapeutics
Volume: 6 Issue: 4
Author(s): Arun K. Rishi, Xinbo Zhang and Anil Wali
Affiliation:
Keywords: Apoptosis, Caspases, p53, IAPs, Mitochondria, Nur77, CARP-1.
Abstract: Apoptosis plays an essential role in the processes of eukaryotic cellular homeostasis, and is thought to be a contributing factor in the development of a variety of pathologies including cancer. Knowledge of the molecular mechanisms and mediators of apoptosis, coupled with the fact that many current anticancer therapies function by activating apoptosis, has led to realization that apoptotic processes not only serve as the crucial regulators of carcinogenesis but are also critical determinants in therapy responses. Defects in apoptosis signaling often lead to ineffective response to anti-cancer therapeutics in the clinic and contribute to development of drug-resistant phenotype. The mediators of apoptosis, therefore, are attractive and rational targets for design and development of apoptosis-promoting strategies to combat cancer. Here we present an overview of different approaches and proof-of-principle evidence for identification, development, and use of agents that target apoptosis signaling in cancer. A synopsis of different apoptosis pathways and the agents, currently in the clinic or in development pipeline, that target mediators of apoptosis is presented. Last, but not least, novel and emerging apoptosis signaling targets with potential utility in anti-cancer drug development are also discussed.
Export Options
About this article
Cite this article as:
K. Rishi Arun, Zhang Xinbo and Wali Anil, Recent Advances and Approaches in Targeting Apoptosis Signaling Pathways for Anti-Cancer Therapeutics, Current Cancer Therapy Reviews 2010; 6 (4) . https://dx.doi.org/10.2174/157339410793358075
DOI https://dx.doi.org/10.2174/157339410793358075 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Monoclonal Antibodies in Clinical Oncology
Anti-Cancer Agents in Medicinal Chemistry Surgical Treatment of Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension
Current Pharmaceutical Design Neuropsychiatric and General Interactions of Natural and Synthetic Cannabinoids with Drugs of Abuse and Medicines
CNS & Neurological Disorders - Drug Targets Cyclopentenone Prostaglandins as Anti-Inflammatory Agents: A Novel Therapeutic Strategy?
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Recent Advances in Sepsis Research: Novel Biomarkers and Therapeutic Targets
Current Medicinal Chemistry To Be-et, or Not to Be-et, That is the Question: The Role(s) of Nitrate and Nitrite in Health and Illness
Reviews on Recent Clinical Trials The Validity of Chemical Analytical Methods by the Example of the Heparin Product Recall
Current Pharmaceutical Analysis Circadian Rhythm of Blood Pressure in Diabetes Mellitus: Evidence, Mechanisms and Implications
Current Diabetes Reviews Scope and Limitations of The Co-Drug Approach to Topical Drug Delivery
Current Pharmaceutical Design Editorial [Hot topic: Controversies in Hypertension Treatment (Guest Editors: Maciej Banach, Sverre E. Kjeldsen and Krzysztof Narkiewicz)]
Current Vascular Pharmacology Cardiac Amyloidosis Responding to Bortezomib: Case Report and Review of Literature
Current Cardiology Reviews Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System
Mini-Reviews in Medicinal Chemistry Anti-Atherosclerotic Therapy Based on Botanicals
Recent Patents on Cardiovascular Drug Discovery Potential Therapeutic Targets in Cirrhotic Cardiomyopathy
Cardiovascular & Hematological Disorders-Drug Targets Pharmacokinetics of Selegiline in a Rabbit Model
Letters in Drug Design & Discovery The use of Immunoglobulin Therapy in Primary Immunodeficiency Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Fibroblast Growth Factor 2: From Laboratory Evidence to Clinical Application
Current Vascular Pharmacology New Agents to Treat Life-Threatening Fungal Infections
Current Topics in Medicinal Chemistry ABC Transporters, Bile Acids, and Inflammatory Stress in Liver Cancer
Current Pharmaceutical Biotechnology Diabetes and Its Complications: Therapies Available, Anticipated and Aspired
Current Diabetes Reviews